Tesamorelin (INN) (trade name Egrifta SV) is an artificial kind of growth-hormone-releasing hormone (GHRH) which is used in the therapy of HIV-associated lipodystrophy, approved initially in 2010. It is created and developed by Theratechnologies, Inc. of Canada. The medication is a synthetic peptide consisting of all 44 amino acids of human GHRH with the enhancement of a trans-3-hexenoic acid team.
Tesamorelin is a synthetic analog of GHRH. It is specifically designed to bind to GHRH receptors in the anterior pituitary, triggering GH release. Structurally, it mimics the natural hormone but with enhanced stability in the bloodstream.
Key Features of Tesamorelin:
Synthetic origin: Modified for greater efficacy.
Selective action: Targets GHRH receptors exclusively.
Longevity: Designed for a prolonged half-life compared to natural GHRH.
Tesamorelin’s benefits go beyond theory, with proven applications in various medical fields:
HIV-Associated Lipodystrophy:
FDA-approved for reducing visceral adiposity in patients with HIV-associated lipodystrophy.
Result: Significant improvement in body composition and self-image.
Age-Related Conditions:
Potential treatment for sarcopenia (age-related muscle loss).
Supports healthier aging by preserving lean mass and metabolic balance.
Emerging Research:
Studies suggest benefits for managing nonalcoholic fatty liver disease (NAFLD).
Potential cognitive benefits in elderly populations.
Tesamorelin’s functionality revolves around its interaction with the pituitary gland. Here’s how it works:
Binding to Receptors: Tesamorelin binds to GHRH receptors in the anterior pituitary.
GH Secretion: This stimulates somatotroph cells to release GH.
IGF-1 Production: Increased GH levels lead to higher production of insulin-like growth factor 1 (IGF-1) in the liver, which mediates many of GH’s effects.
Physiological Effects of Increased GH Secretion
The effects of Tesamorelin-induced GH secretion extend across several physiological domains:
Metabolism: Improves lipid profiles and aids in fat metabolism.
Muscle Growth: Promotes lean muscle mass development.
Bone Density: Enhances bone health, reducing fracture risks.
Skin Health: May improve skin elasticity and reduce signs of aging.
Implementing Tesamorelin therapy requires careful planning:
Administration and Dosing:
Monitoring:
Adherence Strategies:
| Feature | Tesamorelin | Sermorelin | Ipamorelin |
|---|---|---|---|
| Target Receptor | GHRH receptor | GHRH receptor | GH secretagogue receptor |
| Stability | High | Moderate | High |
| Primary Use | Lipodystrophy, metabolic health | Anti-aging | Muscle recovery |
| Side Effects | Mild to moderate | Mild | Mild |
Tesamorelin is a synthetic peptide that mimics growth hormone-releasing hormone (GHRH). It works by stimulating the pituitary gland to produce and release growth hormone (GH). This activation occurs through the hypothalamic-pituitary axis, a critical regulatory pathway for hormonal balance in the body.
Tesamorelin binds to GHRH receptors in the anterior pituitary gland, located at the base of the hypothalamus. This binding triggers a cascade of events that leads to the secretion of growth hormone. The hypothalamus monitors GH levels and adjusts GHRH release accordingly, maintaining hormonal balance.
Tesamorelin is primarily used for the treatment of HIV-associated lipodystrophy, where it helps reduce visceral adipose tissue. By increasing growth hormone levels, it also promotes fat metabolism, muscle preservation, and improved body composition. Research is exploring its potential applications in age-related conditions and cognitive health.
Common side effects of Tesamorelin include redness or irritation at the injection site, joint pain, and nausea. Some individuals may experience increased blood sugar levels or insulin resistance, so monitoring is essential, especially for people with diabetes or at risk for metabolic disorders.
Tesamorelin temporarily enhances growth hormone secretion while in use. However, its effects are not permanent. Once administration stops, GH levels generally return to baseline. Long-term benefits depend on consistent use and are influenced by the body's natural capacity to regulate hormone production.
